Type-2 diabetes and risk of dementia: observational and Mendelian randomisation studies in 1 million individuals.

ABSTRACT:

Aims

In observational studies, type-2 diabetes is associated with increased risk of dementia; however, the causal nature of this association remains unanswered. In an unselected nationwide study of all Danes, we wanted to test whether type-2 diabetes is associated with dementia subtypes, and to test whether potential associations are of a causal nature.

Methods

In the current study of nationwide observational registry data in all Danes above the age of 65 years (n = 784 434) combined with genetic consortia data on 213 370 individuals, we investigated the associations between type-2 diabetes and Alzheimer's disease, vascular dementia, unspecified dementia and all-cause dementia, and whether observational associations were of a causal nature by applying a two-sample Mendelian

SUBMITTER: Thomassen JQ 

PROVIDER: S-EPMC7214711 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature