NtrBC Regulates Invasiveness and Virulence of Pseudomonas aeruginosa During High-Density Infection.

ABSTRACT: Pseudomonas aeruginosa is an opportunistic pathogen that is a major cause of nosocomial and chronic infections contributing to morbidity and mortality in cystic fibrosis patients. One of the reasons for its success as a pathogen is its ability to adapt to a broad range of circumstances. Here, we show the involvement of the general nitrogen regulator NtrBC, which is structurally conserved but functionally diverse across species, in pathogenic and adaptive states of P. aeruginosa. The role of NtrB and NtrC was examined in progressive or chronic infections, which revealed that mutants (ΔntrB, ΔntrC, and ΔntrBC) were reduced in their ability to invade and cause damage in a high-density abscess model in vivo. Progressive infections were established with

SUBMITTER: Alford MA 

PROVIDER: S-EPMC7214821 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature