Bioinformatics and Biosimulations as Toolbox for Peptides and Peptidomimetics Design: Where Are We?

ABSTRACT: Peptides and peptidomimetics are strongly re-emerging as amenable candidates in the development of therapeutic strategies against a plethora of pathologies. In particular, these molecules are extremely suitable to treat diseases in which a major role is played by protein-protein interactions (PPIs). Unlike small organic compounds, peptides display both a high degree of specificity avoiding secondary off-targets effects and a relatively low degree of toxicity. Further advantages are provided by the possibility to easily conjugate peptides to functionalized nanoparticles, so improving their delivery and cellular uptake. In many cases, such molecules need to assume a specific three-dimensional conformation that resembles the bioactive one of the endogenous ligand. To this end, chemical modifi

SUBMITTER: D'Annessa I 

PROVIDER: S-EPMC7214840 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature