Comprehensive molecular characterization of circRNA-associated ceRNA network in constrictive pericarditis.

ABSTRACT:

Background

Aberrant gene expression occurs in almost all diseases including constrictive pericarditis (CP). However, the dysregulation of genes underlying the CP remains unclear. This study aims to investigate the potential molecular mechanisms underlying CP and screen hub genes critical for the pathogenesis of CP.

Methods

Differentially expressed mRNAs, miRNAs, lncRNAs and circRNAs in pericardial tissues were screened using RNA-seq in CP patients and controls. Furthermore, functional annotation analysis and protein-protein interaction (PPI) network were carried out to investigate the potential key pathways and identify hub genes in CP. Subsequently, a ceRNA network was established and the key circRNAs were determined by Gene Set Enrichment Analysis (GSEA). Finally, the corr

SUBMITTER: Chen Y 

PROVIDER: S-EPMC7214901 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature