Decreased Foxp3 and function of Tregs caused immune imbalance and liver injury in patients with autoimmune liver diseases post-liver transplantation.

ABSTRACT:

Background

Autoimmune liver diseases (AILD) is a type of autoimmune disease which may cause end-stage liver failure and require liver transplantation. Regulatory T cells (Tregs) play an irreplaceable role in maintaining immunological homeostasis.

Methods

In this study, we made a comparative analysis of the immune balance and graft function between AILD patients' post-transplantation and the patients who have had liver failure with hepatitis B virus (HBV) infection post-transplantation. Immune cell phenotype of two groups were analyzed. We sorted CD4+CD25+CD127-Tregs both in vitro and vivo and did TSDR methylation status assay to explore further possible mechanisms.

Results

Our data showed that there is a worse prognosis with severe graft function in liver trans

SUBMITTER: Liu Z 

PROVIDER: S-EPMC7214902 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature