Comprehensive analysis of competing endogenous RNA network in Wilms tumor based on the TARGET database.

ABSTRACT:

Background

Wilms tumor (WT) was the most common malignant tumor of urinary system in children. With the advances in gene sequencing, research of molecular mechanism of WT tumor was gradually increasing. However, few studies have explored the influence of competing endogenous RNA (ceRNA) in WT. Accordingly, we aimed to explore the mechanisms of ceRNA co-expression network in WT.

Methods

A total of 6 non-tumor controls and 127 WT patients' RNA-seq data combined with clinical data was acquired from Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database. Differentially expressed lncRNA, miRNA and mRNA between WT tissues and normal tissues were analyzed using "edgeR" package in R software. Weighted gene co-expression network analysis (WGCNA) was ut

SUBMITTER: Guan B 

PROVIDER: S-EPMC7214997 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature