Pre-treatment estradiol does not predict testosterone response to clomiphene citrate.

ABSTRACT:

Background

Clomiphene citrate (CC) is a selective estrogen receptor modulator (SERM) used to stimulate ovulation in women. CC is used off-label in men to increase levels of endogenous testosterone (T) while potentially improving semen parameters by downregulating the inhibitory feedback of estradiol (E) on the male hypothalamus. Our objective was to determine whether pre-treatment E level is associated with greater total testosterone (TT) response to treatment with CC in men with low T.

Methods

Following IRB approval (The University of Miami IRB No. 20170849), retrospective chart review was performed for all men prescribed CC (25 mg every other day) between January 1, 2015 and December 31, 2018. Age, body mass index (BMI), and prescription date were recorded for all patients

SUBMITTER: Masterson JM 

PROVIDER: S-EPMC7215015 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature