The effect of ABCB1 polymorphism on sirolimus in renal transplant recipients: a meta-analysis.

ABSTRACT:

Background

Sirolimus (SRL) is an immunosuppressive drug and substrate of the P-glycoprotein (P-GP) encoded by ABCB1. The relationship between ABCB1 polymorphism and the pharmacokinetics of SRL in different studies were conflicting in renal transplant recipients. Thus, this meta-analysis aims to investigate the influence of ABCB1 C3435T, C1236T, and G2677T/A polymorphisms on the dose-adjusted trough level (C/D) of SRL in renal transplant recipients.

Methods

PubMed, Embase, and the Cochrane Library were searched for relevant studies. The quality of each eligible study was assessed according to Newcastle-Ottawa Scale. The STATA 15.0 was adopted to perform the meta-analysis. The fixed-effects model was used for pooled results with low heterogeneity (I^2<

SUBMITTER: Shao S 

PROVIDER: S-EPMC7215018 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature