Drug repositioning or target repositioning: A structural perspective of drug-target-indication relationship for available repurposed drugs.

ABSTRACT: Drug repositioning aims to find new indications for existing drugs in order to reduce drug development cost and time. Currently,there are numerous stories of successful drug repositioning that have been reported and many repurposed drugs are already available on the market. Although drug repositioning is often a product of serendipity, repositioning opportunities can be uncovered systematically. There are three systematic approaches to drug repositioning: disease-centric approach, target-centric and drug-centric. Disease-centric approaches identify close relationships between an old and a new indication. A target-centric approach links a known target and its established drug to a new indication. Lastly, a drug-centric approach connects a known drug to a new target and its associated indica

SUBMITTER: Parisi D 

PROVIDER: S-EPMC7215100 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature