Recruitability and effect of PEEP in SARS-Cov-2-associated acute respiratory distress syndrome.

ABSTRACT:

Background

A large proportion of patients with a SARS-Cov-2-associated respiratory failure develop an acute respiratory distress syndrome (ARDS). It has been recently suggested that SARS-Cov-2-associated ARDS may differ from usual non-SARS-Cov-2-associated ARDS by higher respiratory system compliance (C_RS), lower potential for recruitment with positive end-expiratory pressure (PEEP) contrasting with severe shunt fraction. The purpose of the study was to systematically assess respiratory mechanics and recruitability in SARS-Cov-2-associated ARDS.

Methods

Gas exchanges, C_RS and hemodynamics were assessed at 2 levels of PEEP (15 cmH₂O and 5 cmH₂O) within 36 h (day1) and from 4 to 6 days (day 5) after intubation. The recruited volume w

SUBMITTER: Beloncle FM 

PROVIDER: S-EPMC7215140 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature