Nostoc sphaeroids Kutz ameliorates hyperlipidemia and maintains the intestinal barrier and gut microbiota composition of high-fat diet mice.

ABSTRACT: Hyperlipidemia is associated with chronic inflammation and intestinal dysbiosis. The purpose of this study was to investigate the protective effect of Nostoc sphaeroids Kütz (NO) on diet-induced hyperlipidemia in mice. Experimental animals received a high-fat diet (HFD) for 4 weeks, then an HFD supplemented with 2.5% or 7.5% NO for 6 weeks. HFD-fed mice exhibited a significant increase in serum total cholesterol, triglycerides, and low-density lipid cholesterol, and a decrease in high-density lipid cholesterol. NO supplementation was associated with significantly lower dyslipidemia, decreased intestinal inflammation, and inhibition of toll-like receptor 4 gene repression in HFD-fed mice. Results suggest that NO treatment protected the integrity of the intestinal barrier. NO treatment was a

SUBMITTER: Wei F 

PROVIDER: S-EPMC7215204 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature