Eggshell membrane powder lowers plasma triglyceride and liver total cholesterol by modulating gut microbiota and accelerating lipid metabolism in high-fat diet-fed mice.

ABSTRACT: Obesity is a major global lifestyle disorder associated with gut microbiota. The health benefits of eggshell membrane (ESM) have been shown in previous reports, particularly as regards gut microbiota composition. Here, we investigated whether ESM improves lipid metabolism and alters gut microbiota in high-fat diet-fed mice. A total of 20 C57BL/6J mice aged 6 weeks were given either a control diet (CON), high-fat diet (HFD), or high-fat diet + 8% ESM powder (HESM) for 20 weeks. ESM supplementation in HFD-fed mice reduced plasma triglycerides (TG) and liver total cholesterol (TC) and upregulated the expression of lipid metabolism genes carnitine palmitoyltransferase 1A and suppressor of cytokine signaling 2. Microbiota analysis showed increased relative abundance of the anti-obesity bacteriu

SUBMITTER: Ramli NS 

PROVIDER: S-EPMC7215208 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature