Sex differences in obstructive sleep apnea phenotypes, the multi-ethnic study of atherosclerosis.

ABSTRACT:

Study objectives

The bases for sex disparities in obstructive sleep apnea (OSA), is poorly understood. We quantified the influences of event definitions, sleep-state, and body position on apnea-hypopnea indices (AHIs) in men and women, and evaluated sex differences in pathophysiological endotypes.

Methods

Polysomnography (PSG) data were analyzed from 2057 participants from the multi-ethnic study of atherosclerosis. Alternative AHIs were compared using various desaturation and arousal criteria. Endotypes (loop gain, airway collapsibility, arousal threshold) were derived using breath-by-breath analysis of PSG signals. Regression models estimated the extent to which endotypes explained sex differences in AHI.

Results

The sample (mean 68.5 ± 9.2 years) included 54% women.

SUBMITTER: Won CHJ 

PROVIDER: S-EPMC7215264 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature