Sleep duration over 28 years, cognition, gray matter volume, and white matter microstructure: a prospective cohort study.

ABSTRACT: To examine the association between sleep duration trajectories over 28 years and measures of cognition, gray matter volume, and white matter microstructure. We hypothesize that consistently meeting sleep guidelines that recommend at least 7 hours of sleep per night will be associated with better cognition, greater gray matter volumes, higher fractional anisotropy, and lower radial diffusivity values. We studied 613 participants (age 42.3 ± 5.03 years at baseline) who self-reported sleep duration at five time points between 1985 and 2013, and who had cognitive testing and magnetic resonance imaging administered at a single timepoint between 2012 and 2016. We applied latent class growth analysis to estimate membership into trajectory groups based on self-reported sleep duration over time. An

SUBMITTER: Zitser J 

PROVIDER: S-EPMC7215267 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature