Self-reported sleep relates to hippocampal atrophy across the adult lifespan: results from the Lifebrain consortium.

ABSTRACT:

Objectives

Poor sleep is associated with multiple age-related neurodegenerative and neuropsychiatric conditions. The hippocampus plays a special role in sleep and sleep-dependent cognition, and accelerated hippocampal atrophy is typically seen with higher age. Hence, it is critical to establish how the relationship between sleep and hippocampal volume loss unfolds across the adult lifespan.

Methods

Self-reported sleep measures and MRI-derived hippocampal volumes were obtained from 3105 cognitively normal participants (18-90 years) from major European brain studies in the Lifebrain consortium. Hippocampal volume change was estimated from 5116 MRIs from 1299 participants for whom longitudinal MRIs were available, followed up to 11 years with a mean interval of 3.3 years. Cross

SUBMITTER: Fjell AM 

PROVIDER: S-EPMC7215271 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature