CDKs in Sarcoma: Mediators of Disease and Emerging Therapeutic Targets.

ABSTRACT: Sarcomas represent one of the most challenging tumor types to treat due to their diverse nature and our incomplete understanding of their underlying biology. Recent work suggests cyclin-dependent kinase (CDK) pathway activation is a powerful driver of sarcomagenesis. CDK proteins participate in numerous cellular processes required for normal cell function, but their dysregulation is a hallmark of many pathologies including cancer. The contributions and significance of aberrant CDK activity to sarcoma development, however, is only partly understood. Here, we describe what is known about CDK-related alterations in the most common subtypes of sarcoma and highlight areas that warrant further investigation. As disruptions in CDK pathways appear in most, if not all, subtypes of sarcoma, we discu

SUBMITTER: Kohlmeyer JL 

PROVIDER: S-EPMC7215455 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature