Mechanisms of Action of Autophagy Modulators Dissected by Quantitative Systems Pharmacology Analysis.

ABSTRACT: Autophagy plays an essential role in cell survival/death and functioning. Modulation of autophagy has been recognized as a promising therapeutic strategy against diseases/disorders associated with uncontrolled growth or accumulation of biomolecular aggregates, organelles, or cells including those caused by cancer, aging, neurodegeneration, and liver diseases such as α1-antitrypsin deficiency. Numerous pharmacological agents that enhance or suppress autophagy have been discovered. However, their molecular mechanisms of action are far from clear. Here, we collected a set of 225 autophagy modulators and carried out a comprehensive quantitative systems pharmacology (QSP) analysis of their targets using both existing databases and predictions made by our machine learning algorithm. Autophagy mo

SUBMITTER: Shi Q 

PROVIDER: S-EPMC7215584 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature