Diagnostic Performance of RO948 F 18 Tau Positron Emission Tomography in the Differentiation of Alzheimer Disease From Other Neurodegenerative Disorders.

ABSTRACT:

Importance

The diagnostic performance of second-generation tau positron emission tomographic (PET) tracers is not yet known.

Objective

To examine the novel tau PET tracer RO948 F 18 ([18F]RO948) performance in discriminating Alzheimer disease (AD) from non-AD neurodegenerative disorders.

Design, setting, and participants

In this diagnostic study, 613 participants in the Swedish BioFINDER-2 study were consecutively enrolled in a prospective cross-sectional study from September 4, 2017, to August 28, 2019. Participants included 257 cognitively unimpaired controls, 154 patients with mild cognitive impairment, 100 patients with AD dementia, and 102 with non-AD neurodegenerative disorders. Evaluation included a comparison of tau PET tracer [18F]RO948 with magnetic resonanc

SUBMITTER: Leuzy A 

PROVIDER: S-EPMC7215644 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature