Fluorinated Molecules and Nanotechnology: Future 'Avengers' against the Alzheimer's Disease?

ABSTRACT: Alzheimer's disease (AD) is a serious health concern, affecting millions of people globally, which leads to cognitive impairment, dementia, and inevitable death. There is still no medically accepted treatment for AD. Developing therapeutic treatments for AD is an overwhelming challenge in the medicinal field, as the exact mechanics underlying its devastating symptoms is still not completely understood. Rather than the unknown mechanism of the disease, one of the limiting factors in developing new drugs for AD is the blood-brain barrier (BBB). A combination of nanotechnology with fluorinated molecules is proposed as a promising therapeutic treatment to meet the desired pharmacokinetic/physiochemical properties for crossing the BBB passage. This paper reviews the research conducted on fluori

SUBMITTER: Dabur M 

PROVIDER: S-EPMC7216102 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature