Immunoproteasome Genes Are Modulated in CD34⁺ JAK2^V617F Mutated Cells from Primary Myelofibrosis Patients.

ABSTRACT: Primary myelofibrosis (PMF) is a rare myeloproliferative neoplasm characterized by stem-cell-derived clonal over-proliferation of mature myeloid lineages, bone marrow fibrosis, osteosclerosis, defective erythropoiesis, and pro-inflammatory cytokine over-expression. The aim of the present study was to highlight possible differences in the transcriptome among CD34⁺ cells from peripheral blood (PB) of PMF patients. Therefore, we merged two microarray datasets of healthy control subjects and PMF (34 JAK2^V617F MUTATED and 28 JAK2 wild-type). The GO analysis of upregulated genes revealed enrichment for JAK2/STAT1 pathway gene set in PB CD34⁺ cells of PMF patients with and without the JAK2^V617F mutation comparing to the healthy control subjects,

SUBMITTER: Di Rosa M 

PROVIDER: S-EPMC7216198 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature