Differential Expression and Function of Bicellular Tight Junctions in Skin and Oral Wound Healing.

ABSTRACT: Bicellular tight junctions are multiprotein complexes that are required for maintenance of barrier function and fence function in epithelial tissues. Wound healing in the oral cavity leads to minimal scar formation compared to the skin, and the precise mechanisms for this regenerative response remain to be elucidated. We hypothesized that oral and skin tissues express a different tight junction repertoire both at baseline and during the wound healing response, and that these molecules may be critical to the differential repair between the two tissues. We re-analyzed a mouse skin and palate epithelium microarray dataset to identify the tight junction repertoire of these tissue types. We then re-analyzed a skin and tongue wound healing microarray dataset to see how expression levels of tight

SUBMITTER: Leonardo TR 

PROVIDER: S-EPMC7216202 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature