Heavy chain deposition disease presenting with raised anti-GBM antibody levels; a case report.

ABSTRACT:

Background

Monoclonal immunoglobulin deposition disease (MIDD) is a rare condition accounting for < 1% of histopathological diagnoses made on kidney biopsy¹. The best outcomes are seen in those diagnosed and treated promptly, but delay to diagnosis is common with the largest series reporting a median time from onset of renal impairment to diagnosis of 12 months². Here, we report a case of the heavy chain subset of MIDD presenting with positive anti-glomerular basement membrane (anti-GBM) antibodies obscuring the true diagnosis.

Case presentation

Here, we present a challenging case presenting with oedema, haematoproteiuria, and new renal impairment. Anti-GBM antibodies were positive and prompted treatment as atypical anti-GBM disease. However, they were

SUBMITTER: Turner M 

PROVIDER: S-EPMC7216388 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature