Efficacy and safety of IL-17 inhibitors for the treatment of ankylosing spondylitis: a systematic review and meta-analysis.

ABSTRACT:

Objectives

To systematically assess the efficacy and safety of IL-17 inhibitors in patients with active ankylosing spondylitis.

Methods

A systematic review of the literature was performed for randomized controlled trials (RCTs) concerning IL-17 inhibitors in patients with ankylosing spondylitis. Meta-analyses were used to determine the efficacy and safety of the IL-17 inhibitors in the treatment of these patients. The primary endpoint was predefined as the proportion of patients with at least 20% improvement in the Assessment of Spondyloarthritis International Society (ASAS20) response criteria at week 16, and the secondary endpoint was defined as ASAS40 at week 16.

Results

Six phase III randomized, double-blind, placebo-controlled trials including 1733 patients (1153

SUBMITTER: Yin Y 

PROVIDER: S-EPMC7216398 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature