Host DNA contents in fecal metagenomics as a biomarker for intestinal diseases and effective treatment.

ABSTRACT:

Background

Compromised intestinal barrier (CIB) has been associated with many enteropathies, including colorectal cancer (CRC) and inflammatory bowel disease (IBD). We hypothesized that CIB could lead to increased host-derived contents including epithelial cells into the gut, change its physio-metabolic properties, and globally alter microbial community and metabolic capacities.

Results

Consistently, we found host DNA contents (HDCs), calculated as the percentage of metagenomic sequencing reads mapped to the host genome, were significantly elevated in patients of CRC and Crohn's disease (CD). Consistent with our hypothesis, we found that HDC correlated with microbial- and metabolic-biomarkers of these diseases, contributed significantly to machine-learning models for patient

SUBMITTER: Jiang P 

PROVIDER: S-EPMC7216530 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature