Increased serum calpain activity is associated with HMGB1 levels in systemic sclerosis.

ABSTRACT:

Background

Systemic sclerosis (SSc) or scleroderma is an intractable autoimmune disorder that affects multiple organs. The objectives were to investigate clinical correlations of serum calpain activity and high mobility group box 1 (HMGB1) levels with immunological and clinical traits.

Methods

A total of 31 patients with SSc, 20 age- and gender-matched healthy control subjects (HC), and 10 patients with other connective tissue diseases (CTD) were recruited in the study. We measured serum calpain activity and HMGB1 levels and analyzed the datasets (GSE40839, GSE48149, GSE76808, GSE81292, GSE33463, and GSE58095) from Gene Expression Omnibus (GEO) database to explore the potential mechanism by which calpain exerts its function through bioinformatics methods.

Results

Seru

SUBMITTER: Zheng JN 

PROVIDER: S-EPMC7216546 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature