Prostaglandin E₂ affects in vitro maturation of bovine oocytes.

ABSTRACT: The role of prostaglandin E₂ (PGE₂) in the successful resumption of oocyte meiosis and cumulus expansion has been well-documented. However, there remains very little information available on the influence of PGE₂ on other processes that occur during oocyte maturation. In this study, we supplemented a maturation medium with PGE₂ and monitored oocyte quality markers, glucose metabolism, mitochondrial status, oxidative stress, and apoptosis in the cumulus-oocyte complexes (COCs), using a well-established in vitro model of embryo production in cattle. We found that this increased availability of PGE₂ during maturation led to an increase in the expression of genes associated with oocyte competence and improved the quality of blastocysts pro

SUBMITTER: Boruszewska D 

PROVIDER: S-EPMC7216604 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature