Insulin resistance contributes to racial disparities in breast cancer prognosis in US women.

ABSTRACT:

Background

Racial disparities in breast cancer survival between Black and White women persist across all stages of breast cancer. The metabolic syndrome (MetS) of insulin resistance disproportionately affects more Black than White women. It has not been discerned if insulin resistance mediates the link between race and poor prognosis in breast cancer. We aimed to determine whether insulin resistance mediates in part the association between race and breast cancer prognosis, and if insulin receptor (IR) and insulin-like growth factor receptor (IGF-1R) expression differs between tumors from Black and White women.

Methods

We conducted a cross-sectional, multi-center study across ten hospitals. Self-identified Black women and White women with newly diagnosed invasive breast cance

SUBMITTER: Gallagher EJ 

PROVIDER: S-EPMC7216707 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature