The use of urinary biomarkers to predict acute kidney injury in children after liver transplant.

ABSTRACT:

Background

AKI after pediatric liver transplantation is associated with increased morbidity and mortality. The role of urinary biomarkers for the prediction of AKI in pediatric patients after liver transplantation has not been previously reported. The primary objective of this prospective pilot study was to determine the predictive capabilities of urinary KIM-1, NGAL, TIMP-2, and IGFBP7 for diagnosing AKI.

Methods

Sixteen children undergoing liver transplantation were enrolled in the study over a 19-month time period. The Kidney Disease Improving Outcomes criteria for urine output and serum creatinine were used to define AKI. Predictive ability was evaluated using the area under the curve obtained by ROC analysis.

Results

AKI occurred in 6 (37.5%) of the patients betw

SUBMITTER: Fuhrman DY 

PROVIDER: S-EPMC7216780 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature