Association between CYP2B6 polymorphism and acute leukemia in a Han population of Northwest China.

ABSTRACT:

Background

The aim of this study was to investigate potential associations between CYP2B6 c.516G>T polymorphism and the occurrence and prognosis of acute leukemias (AL) in the Han population of Northwest China.

Methods

The CYP2B6 gene polymorphism was analyzed by PCR-RFLP and Sanger DNA sequencing in 126 patients with AL and 161 healthy controls.

Results

Compared with controls, there were significantly higher frequencies of GT and TT genotypes and T alleles in AL patients (p < .05), particularly in fusion gene-positive AL patients. There was no significant difference in CYP2B6 polymorphic genotypes and T alleles between AL patients with complete remission after the first course of chemotherapy and controls (p > .05), while the frequencies in AL patients with partial r

SUBMITTER: Yu LL 

PROVIDER: S-EPMC7216805 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature