Magnetization transfer and frequency distribution effects in the SSFP ellipse.

ABSTRACT:

Purpose

To demonstrate that quantitative magnetization transfer (qMT) parameters can be extracted from steady-state free-precession (SSFP) data with no external T₁ map or banding artifacts.

Methods

SSFP images with multiple MT weightings were acquired and qMT parameters fitted with a two-stage elliptical signal model.

Results

Monte Carlo simulations and data from a 3T scanner indicated that most qMT parameters could be recovered with reasonable accuracy. Systematic deviations from theory were observed in white matter, consistent with previous literature on frequency distribution effects.

Conclusions

qMT parameters can be extracted from SSFP data alone, in a manner robust to banding artifacts, despite several confounds.

SUBMITTER: Wood TC 

PROVIDER: S-EPMC7216875 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature