Maternal Glucose Concentrations in Early Pregnancy and Cardiometabolic Risk Factors in Childhood.

ABSTRACT:

Objective

This study aimed to examine the associations of maternal early-pregnancy glucose and insulin concentrations with offspring cardiometabolic risk factors and fat distribution.

Methods

In a population-based prospective cohort study among 3,737 mothers and their children, random maternal glucose and insulin concentrations were measured at a median gestational age of 13.2 (95% range 10.5-17.1) weeks. Childhood fat, blood pressure, and blood concentrations of lipids, glucose, and insulin at the age of 10 years were measured.

Results

Higher maternal early-pregnancy glucose and insulin concentrations were associated with a higher risk of childhood overweight, and higher maternal early-pregnancy insulin concentrations were associated with an increased childhood risk

SUBMITTER: Wahab RJ 

PROVIDER: S-EPMC7216879 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature