Differentiation of skeletal muscle Mesenchymal progenitor cells to myofibroblasts is reversible.

ABSTRACT: Accumulation of intramuscular adipose tissue (IMAT) and development of fibrous tissues due to accumulation of collagen both affect meat quality such as tenderness, texture, and flavor. Thus, it is important for the production of high-quality meat to regulate the amount of adipose and fibrous tissues in skeletal muscle. IMAT is comprised of adipocytes, while collagens included in fibrous tissues are mainly produced by activated fibroblasts. Both adipocytes and fibroblasts are differentiated from their common ancestors, called mesenchymal progenitor cells (MPC). We previously established rat MPC clone, 2G11 cells. As several reports implicated the plasticity of fibroblast differentiation, in the present study, using 2G11 cells, we asked whether myofibroblasts differentiated from MPC are capa

SUBMITTER: Takeuchi S 

PROVIDER: S-EPMC7216888 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature