Fatty acids and recurrence of major depressive disorder: combined analysis of two Dutch clinical cohorts.

ABSTRACT:

Objective

Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acid (PUFA) alterations in patients with major depressive disorder (MDD) have been shown to persist after remission. Whether these alterations are risk factors for MDD recurrence remains unknown. Here, we examined whether fatty acids predict time until MDD recurrence in remitted MDD patients.

Methods

Data were used from remitted MDD patients of the Netherlands Study of Depression and Anxiety (n = 356) and the Depression Evaluation Longitudinal Therapy Assessment studies (n = 118). Associations of FAs with time until MDD recurrence up to 8-year follow-up were analyzed using Cox regression analyses. Study-specific estimates were pooled using mega- and meta-analysis techniques.

Results

27.5% (NESDA) and 56.8

SUBMITTER: Thesing CS 

PROVIDER: S-EPMC7216896 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature