Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine.

ABSTRACT: Chronic obstructive pulmonary disease (COPD) is a devastating lung disease with a high personal and societal burden. Exposure to toxic particles and gases, including cigarette smoke, is the main risk factor for COPD. Together with smoking cessation, current treatment strategies of COPD aim to improve symptoms and prevent exacerbations, but there is no disease-modifying treatment. The biggest drawback of today's COPD treatment regimen is the 'one size fits all' pharmacological intervention, mainly based on disease severity and symptoms and not the individual's disease pathology. To halt the worrying increase in the burden of COPD, disease management needs to be advanced with a focus on personalized treatment. The main pathological feature of COPD includes a chronic and abnormal inflammatory

SUBMITTER: Brandsma CA 

PROVIDER: S-EPMC7216938 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature