Design and Evaluation of a Rodent-Specific Transcranial Magnetic Stimulation Coil: An In Silico and In Vivo Validation Study.

ABSTRACT:

Background

Rodent models are fundamental in unraveling cellular and molecular mechanisms of transcranial magnetic stimulation (TMS)-induced effects on the brain. However, proper translation of human TMS protocols to animal models have been restricted by the lack of rodent-specific focal TMS coils.

Objective

We aimed to improve TMS focalization in rodent brain with a novel small, cooled, and rodent-specific TMS coil.

Methods

A rodent-specific 25-mm figure-of-eight TMS coil was developed. Stimulation focalization was simulated in silico for the rodent coil and a commercial human 50-mm figure-of-eight TMS coil. Both coils were also compared in vivo by electromyography measurements of brachialis motor evoked potential (MEP) responses to TMS at different brain sites in ane

SUBMITTER: Boonzaier J 

PROVIDER: S-EPMC7216963 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature