Trajectories of depression symptom change during and following treatment in adolescents with unipolar major depression.

ABSTRACT:

Objective

To classify a cohort of depressed adolescents recruited to the UK IMPACT trial, according to trajectories of symptom change. We examined for predictors and compared the data-driven categories of patients with a priori operational definitions of treatment response.

Method

Secondary data analysis using growth mixture modelling (GMM). Missing data were imputed. Trajectories of self-reported depressive symptoms were plotted using scores taken at six nominal time points over 86 weeks from randomisation in all 465 patients.

Results

A piecewise GMM categorised patients into two classes with initially similar and subsequently distinct trajectories. Both groups had a significant decline in depressive symptoms over the first 18 weeks. Eighty-four per cent (84.1%, n = 

SUBMITTER: Davies SE 

PROVIDER: S-EPMC7216986 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature