Time Course of Evolving Ventilator-Induced Lung Injury: The "Shrinking Baby Lung".

ABSTRACT:

Objectives

To examine the potentially modifiable drivers that injure and heal the "baby lung" of acute respiratory distress syndrome and describe a rational clinical approach to favor benefit.

Data sources

Published experimental studies and clinical papers that address varied aspects of ventilator-induced lung injury pathogenesis and its consequences.

Study selection

Published information relevant to the novel hypothesis of progressive lung vulnerability and to the biophysical responses of lung injury and repair.

Data extraction

None.

Data synthesis

In acute respiratory distress syndrome, the reduced size and capacity for gas exchange of the functioning "baby lung" imply loss of ventilatory capability that dwindles in proportion to severity of lung injur

SUBMITTER: Marini JJ 

PROVIDER: S-EPMC7217130 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature