Interaction of MOPS buffer with glass-ceramic scaffold: Effect of (PO₄ )^3- ions in SBF on kinetics and morphology of formatted hydroxyapatite.

ABSTRACT: The international standard ISO 23317:2014 for the in vitro testing of inorganic biomaterials in simulated body fluid (SBF) uses TRIS buffer to maintain neutral pH. In our previous papers, we investigated the interaction of a glass-ceramic scaffold with TRIS and HEPES buffers. Both of them speeded up glass-ceramic dissolution and hydroxyapatite (HAp) precipitation, thereby demonstrating their unsuitability for the in vitro testing of highly reactive biomaterials. In this article, we tested MOPS buffer (3-[N-morpholino] propanesulfonic acid), another amino acid from the group of "Goods buffers". A highly reactive glass-ceramic scaffold (derived from Bioglass®) was exposed to SBF under static-dynamic conditions for 13/15 days. The kinetics and morphology of the newly precipitated HAp were stu

SUBMITTER: Horkavcova D 

PROVIDER: S-EPMC7217194 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature