Nuclear positioning facilitates amoeboid migration along the path of least resistance.

ABSTRACT: During metazoan development, immune surveillance and cancer dissemination, cells migrate in complex three-dimensional microenvironments^1-3. These spaces are crowded by cells and extracellular matrix, generating mazes with differently sized gaps that are typically smaller than the diameter of the migrating cell^4,5. Most mesenchymal and epithelial cells and some-but not all-cancer cells actively generate their migratory path using pericellular tissue proteolysis⁶. By contrast, amoeboid cells such as leukocytes use non-destructive strategies of locomotion⁷, raising the question how these extremely fast cells navigate through dense tissues. Here we reveal that leukocytes sample their immediate vicinity for large pore sizes, and are thereby able to ch

SUBMITTER: Renkawitz J 

PROVIDER: S-EPMC7217284 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature