Plasma Biomarkers of Tubular Injury and Inflammation Are Associated with CKD Progression in Children.

ABSTRACT:

Background

After accounting for known risk factors for CKD progression in children, clinical outcomes among children with CKD still vary substantially. Biomarkers of tubular injury (such as KIM-1), repair (such as YKL-40), or inflammation (such as MCP-1, suPAR, TNF receptor-1 [TNFR-1], and TNFR-2) may identify children with CKD at risk for GFR decline.

Methods

We investigated whether plasma KIM-1, YKL-40, MCP-1, suPAR, TNFR-1, and TNFR-2 are associated with GFR decline in children with CKD and in subgroups defined by glomerular versus nonglomerular cause of CKD. We studied participants of the prospective CKiD Cohort Study which enrolled children with an eGFR of 30-90 ml/min per 1.73 m² and then assessed eGFR annually. Biomarkers were measured in plasma collected 5

SUBMITTER: Greenberg JH 

PROVIDER: S-EPMC7217410 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature