Integrating oral PrEP delivery among African women in a large HIV endpoint-driven clinical trial.

ABSTRACT:

Introduction

Global guidelines emphasize the ethical obligation of investigators to help participants in HIV-endpoint trials reduce HIV risk by offering an optimal HIV prevention package. Oral pre-exposure prophylaxis (PrEP) has increasingly become part of state-of-the-art HIV prevention. Here we describe the process of integrating oral PrEP delivery into the HIV prevention package of the Evidence for Contraceptive Options and HIV Outcomes (ECHO) Trial.

Methods

ECHO was an open-label randomized clinical trial that compared HIV incidence among women randomized to one of three effective contraceptives. In total, 7830 women aged 16 to 35 years from 12 sites in four African countries (Eswatini, Kenya, South Africa and Zambia) were enrolled and followed for 12 to 18 months, from

SUBMITTER: Beesham I 

PROVIDER: S-EPMC7217491 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature