Comparative Performance and Neuropathologic Validation of the AD8 Dementia Screening Instrument.

ABSTRACT:

Background/objective

The AD8 informant-based screening instrument has been validated with molecular biomarkers of Alzheimer disease (AD) but not with the gold standard of neuropathologic AD. The objective of this study was to validate the AD8 with neuropathologic AD and compare its predictive performance with that of the Mini-Mental State Examination and both participant-derived and informant-derived subjective memory complaint (SMC) regarding the participant.

Methods

This longitudinal cohort study at the Knight Alzheimer Disease Research Center at Washington University included 230 participants, ages 50 to 91 years, who later had a neuropathologic examination. Four dementia screening instruments from their baseline assessment were evaluated: the AD8, Mini-Mental State Exami

SUBMITTER: Morris GM 

PROVIDER: S-EPMC7217744 | biostudies-literature | 2020 Apr-Jun

REPOSITORIES: biostudies-literature