Prefrontal Regulation of Punished Ethanol Self-administration.

ABSTRACT:

Background

A clinical hallmark of alcohol use disorder is persistent drinking despite potential adverse consequences. The ventromedial prefrontal cortex (vmPFC) and dorsomedial prefrontal cortex (dmPFC) are positioned to exert top-down control over subcortical regions, such as the nucleus accumbens shell (NAcS) and basolateral amygdala, which encode positive and negative valence of ethanol (EtOH)-related stimuli. Prior rodent studies have implicated these regions in regulation of punished EtOH self-administration (EtOH-SA).

Methods

We conducted in vivo electrophysiological recordings in mouse vmPFC and dmPFC to obtain neuronal correlates of footshock-punished EtOH-SA. Ex vivo recordings were performed in NAcS D₁ receptor-expressing medium spiny neurons receiving v

SUBMITTER: Halladay LR 

PROVIDER: S-EPMC7217757 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature