Identification and validation of an immunogenic subtype of gastric cancer with abundant intratumoural CD103⁺CD8⁺ T cells conferring favourable prognosis.

ABSTRACT:

Background

Intratumoural CD103⁺CD8⁺ T cells have been linked to prolonged survival in several malignancies. However, the clinical significance of CD103⁺CD8⁺ T cells in gastric cancer remains unexplored.

Methods

Gastric cancer tissues from Zhongshan Hospital and data from Gene Expression Omnibus were obtained and analysed. Immunohistochemistry and flow cytometry were performed to detect the number and phenotypical characteristics of CD103⁺CD8⁺ T cells. The effect of programmed cell death protein-1 (PD-1) blockade on CD103⁺CD8⁺ T cells was evaluated with the use of an in vitro study based on fresh tumour tissues.

Results

CD103⁺CD8⁺ T cells predicted superior ove

SUBMITTER: Li R 

PROVIDER: S-EPMC7217759 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature