DAXX inhibits cancer stemness and epithelial-mesenchymal transition in gastric cancer.

ABSTRACT:

Background

DAXX is a transcription repressor that has been implicated in several types of cancers, but its role in the development of gastric cancer remains unknown.

Methods

We analysed the expression of DAXX in 83 pairs of gastric cancer samples, including neoplastic and adjacent tissues, and correlated the expression levels with clinical stages. We also investigated the molecular mechanisms by which DAXX downregulation promotes cancer growth using both in vitro and in vivo models.

Results

DAXX was downregulated in advanced gastric cancer samples. The expression of DAXX inversely correlates with that of cancer stem cell markers CD44 and Oct4 in gastric cancer lines. DAXX overexpression in gastric cancer cells inhibited migration, invasion and epithelial- mesenchymal

SUBMITTER: Wu C 

PROVIDER: S-EPMC7217831 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature