Characteristics of gray matter alterations in never-treated and treated chronic schizophrenia patients.

ABSTRACT: Though gray matter deficits have been consistently revealed in chronic treated schizophrenia, it is still not clear whether there are different brain alterations between chronic never treated and treated patients. To explore the different patterns of gray matter alterations among chronic never treated patients and those treated with monotherapy, we recruited 35 never-treated chronic schizophrenia patients with illness durations ranging from 5 to 48 years, 20 illness duration-matched risperidone monotherapy and 20 clozapine monotherapy patients, and 55 healthy controls. GM (surface area, cortical thickness, and cortical volume) measures were extracted and compared using ANCOVA across the four groups followed by post hoc tests. Relative to controls, both treated and never-treated chronic sch

SUBMITTER: Liu N 

PROVIDER: S-EPMC7217843 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature