ZNF746/PARIS overexpression induces cellular senescence through FoxO1/p21 axis activation in myoblasts.

ABSTRACT: Various stresses, including oxidative stress, impair the proliferative capacity of muscle stem cells leading to declined muscle regeneration related to aging or muscle diseases. ZNF746 (PARIS) is originally identified as a substrate of E3 ligase Parkin and its accumulation is associated with Parkinson's disease. In this study, we investigated the role of PARIS in myoblast function. PARIS is expressed in myoblasts and decreased during differentiation. PARIS overexpression decreased both proliferation and differentiation of myoblasts without inducing cell death, whereas PARIS depletion enhanced myoblast differentiation. Interestingly, high levels of PARIS in myoblasts or fibroblasts induced cellular senescence with alterations in gene expression associated with p53 signaling, inflammation, a

SUBMITTER: Bae JH 

PROVIDER: S-EPMC7217926 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature