Epithelial invagination by a vertical telescoping cell movement in mammalian salivary glands and teeth.

ABSTRACT: Epithelial bending is a fundamental process that shapes organs during development. Previously known mechanisms involve cells locally changing shape from columnar to wedge-shaped. Here we report a different mechanism that occurs without cell wedging. In mammalian salivary glands and teeth, we show that initial invagination occurs through coordinated vertical cell movement: cells towards the periphery of the placode move vertically upwards while their more central neighbours move downwards. Movement is achieved by active cell-on-cell migration: outer cells migrate with apical, centripetally polarised leading edge protrusions but remain attached to the basal lamina, depressing more central neighbours to "telescope" the epithelium downwards into underlying mesenchyme. Inhibiting protrusion for

SUBMITTER: Li J 

PROVIDER: S-EPMC7217937 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature