Local Activation of the Alternative Pathway of Complement System in Mycotic Keratitis Patient Tear.

ABSTRACT: Aspergillus flavus and Fusarium solani are the predominant causative agents of mycotic keratitis in the tropical part of the world. Tear proteins play a major role in the innate immune response against these fungal infections as has been shown by the presence of complement proteins and neutrophil extracellular trap proteins in keratitis patients tear. In this study, we established the presence of the components of the alternate pathway of complement system and their functional state in the tear film of mycotic keratitis patients. The complement proteins namely, C3 and CFH were found only in the open-eye tear of patients but not in control individuals. In vitro analysis showed binding of purified C3b and CFH to fungal spores, which confirmed that the spores can provide a forei

SUBMITTER: Shait Mohammed MR 

PROVIDER: S-EPMC7218074 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature