The relationship between lifestyle and serum neurofilament light protein in Huntington's disease.

ABSTRACT:

Objectives

Serum neurofilament light protein (NfL) is a promising marker of disease onset and progression in Huntington's disease (HD). This study investigated associations between lifestyle factors and NfL levels in HD mutation carriers compared to healthy age- and sex-matched controls.

Materials and methods

Participants included 29 HD mutation carriers and 15 healthy controls. Associations between serum NfL concentrations and lifestyle factors, including cardiorespiratory fitness, social network size and diversity, physical activity, cognitive reserve, smoking status, and alcohol consumption, were examined using a stepwise multivariable linear regression model.

Results

Higher NfL levels were associated with lower cognitive reserve, social network size and diversity

SUBMITTER: Cruickshank T 

PROVIDER: S-EPMC7218250 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature